A Green Potentiometric Application for Selective Monitoring of Doxylamine Succinate Dissolution Profile in Combined Dosage Form

نویسندگان

  • Dina Ahmed Pharmaceutical chemistry department, Faculty of pharmaceutical science and pharmaceutical industries, Future University in Egypt, Cairo, Egypt
  • Hayam Lotfy Pharmaceutical chemistry department, Faculty of pharmaceutical science and pharmaceutical industries, Future University in Egypt, Cairo, Egypt
  • Mohamed El-Rahman Analytical chemistry department, Faculty of pharmacy, Cairo University, Cairo, Egypt
  • Soheir Weshahy Analytical chemistry department, Faculty of pharmacy, Cairo University, Cairo, Egypt
چکیده مقاله:

"Green analytical chemistry" (GAC) succeeded to become an eco-friendly environmental crucial area in the field of analytical chemistry targeting at the chemical processes' and products' optimization regarding to material consumption, generation of waste and intrinsic safety, toxicity and environmental burdens. For an expressive comparison, an electro-analytical in-line potentiometric selective determination of Doxylamine succinate (DOX) in a multi- component pharmaceutical dosage form containing both Caffeine (CAF) and Paracetamol (PAR) has been successfully developed and validated. A real-time monitoring of the dissolution profile of DOX from its pharmaceutical formulation was achieved by the proposed sensor without any interference from paracetamol or caffeine even without pretreating neither the sample nor its derivatization. A cationic exchanger; Potassium tetrakis (4-chlorophenyl) borate (KTCPB), polyvinyl chloride (PVC) based membrane and a plasticizer; 2-nitrophenyl-octyl-ether (2-NPOE) were employed for the fabrication DOX-selective sensor. The proposed sensor showed Nernstian response slope of 29.8 mV/concentration decades from 10-6 to 10-2 mol L-1. ICH guidelines' validation parameters; linearity, accuracy, precision and robustness were performed on the proposed green eco-friendly potentiometric method.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Application of oxybutynin selective sensors for monitoring the dissolution profile and assay of pharmaceutical dosage forms.

Two ion-selective sensors of the plastic membrane type were prepared for the determination of oxybutynin hydrochloride (OxCl). They depend on the incorporation of the ion-associates with phosphotungestic acid or phosphomolybdic acid in a PVC matrix. A comparative study is made between their performance characteristics in batch and FIA conditions. The sensors have nearly the same usable concentr...

متن کامل

Potentiometric Method to Determine Montelukast Sodium in its Tablets with In-line Monitoring of its Dissolution Behaviour

Direct drug determination without any pervious treatment steps is the most environmentally friendly method of analysis. Traditional analysis methods usually involve a pre-treatment step before analysis and this consumes time and organic solvents. This work describes direct potentiometric method by using ion selective electrode to determine Montelukast Sodium in its pure drug substance and in ta...

متن کامل

Absorption Correction Method for Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Combined Tablet Dosage Form

A new, simple, precise, accurate and sensitive UV ‐ Spectrophotometric absorption correction method has been developed for simultaneous determination of Metoprolol Succinate and Olmesartan Medoxomil in combined tablet dosage form. Methanol was used as solvent. Absorbance correction method was based on the property of additivity of absorbances. The two wavelengths on Olmesartan medoxomil curve w...

متن کامل

an application of equilibrium model for crude oil tanker ships insurance futures in iran

با توجه به تحریم های بین المملی علیه صنعت بیمه ایران امکان استفاده از بازارهای بین المملی بیمه ای برای نفتکش های ایرانی وجود ندارد. از طرفی از آنجایی که یکی از نوآوری های اخیر استفاده از بازارهای مالی به منظور ریسک های فاجعه آمیز می باشد. از اینرو در این پایان نامه سعی شده است با استفاده از این نوآوری ها با طراحی اوراق اختیارات راهی نو جهت بیمه گردن نفت کش های ایرانی ارائه نمود. از آنجایی که بر...

HPTLC-densitometry method development and validation for simultaneous determination of abacavir, lamivudine and zidovudine in combined dosage form

A simple, accurate and precise HPTLC- densitometry method for the simultaneousdetermination of abacavir, lamivudine and zidovudine in pharmaceutical tablet has beendeveloped. Separation of tablet components was performed on aluminum backed HPTLC plates(silica gel 60 F254 20×20 cm with 0.2 mm thickness, Camag, Muttenz, Switzerland ) usingmethanol : chloroform : acetonitrile (4 : 8 : 3 v/v). Good...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 12  شماره 7

صفحات  989- 1001

تاریخ انتشار 2020-07-31

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023